Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Piezo1 is a mechanosensitive ion channel that has gained recognition for its role in
regulating diverse physiological processes. However, the influence of Piezo1 in …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Despite
significant progress that has been made in therapies against CRC over the past decades …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment
(TME) is critical to suppress tumor development and progression, primarily via maintaining …

Myeloid-derived suppressor cells (MDSCs) are important components of the tumor
microenvironment (TME), which drive the tumor immune escape by inducing …

Background Epigenetic alterations are known contributors to cancer development and
aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are …

Myeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group
of immature cells derived from bone marrow and play critical immunosuppressive functions …