Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies

AM Karim, JE Kwon, T Ali, J Jang, I Ullah… - Biochemical …, 2023 - Elsevier
Long-standing scarcity of efficacious treatments and tumor heterogeneity have contributed to
triple-negative breast cancer (TNBC), a subtype with a poor prognosis and aggressive …

Artificial intelligence: opportunities and challenges in the clinical applications of triple-negative breast cancer

J Guo, J Hu, Y Zheng, S Zhao, J Ma - British Journal of Cancer, 2023 - nature.com
Triple-negative breast cancer (TNBC) accounts for 15–20% of all invasive breast cancer
subtypes. Owing to its clinical characteristics, such as the lack of effective therapeutic …

Paraoxonase-2 is upregulated in triple negative breast cancer and contributes to tumor progression and chemoresistance

R Campagna, V Pozzi, S Giorgini, D Morichetti… - Human Cell, 2023 - Springer
Triple negative breast cancer (TNBC) displays a high aggressive behavior, tendency to
relapse and early metastasize, leading to poor prognosis. The lack of estrogen receptors …

Multifunctional nanoparticles inhibit tumor and tumor-associated macrophages for triple-negative breast cancer therapy

Y Liu, D Zhang, Z Zhang, X Liang, X Yang… - Journal of colloid and …, 2024 - Elsevier
Hypothesis Tumor-associated macrophages (TAM) are the mainstay of immunosuppressive
cells in the tumor microenvironment, and elimination of M2-type macrophages (M2-TAM) is …

Mitochondria Targeted Nanoparticles Potentiate Tumor Chemo‐Phototherapy by Toxic Oxidative Stress Mediated Oxeiptosis

Z Lu, J Li, B Chen, J Feng, Q Hu… - Macromolecular …, 2023 - Wiley Online Library
Insufficient accumulation of drug at the tumor site and the low drug response are the main
reason for the unsatisfactory effect of cancer therapy. Delivery drugs exquisitely to …

Photosensitive small extracellular vesicles regulate the immune microenvironment of triple negative breast cancer

Y Ding, H Ding, H Li, R Yang, J Huang, H Chen… - Acta Biomaterialia, 2023 - Elsevier
Currently, the treatment of triple-negative breast cancer (TNBC) is limited by the special
pathological characteristics of this disease. In recent years, photodynamic therapy (PDT) has …

Locoregional recurrence in triple negative breast cancer: past, present, and future

J Tran, A Thaper, N Lopetegui-Lia… - Expert Review of …, 2023 - Taylor & Francis
Introduction Triple negative breast cancer (TNBC) is a rare but aggressive biological
subtype of breast cancer associated with higher locoregional and distant recurrence rates …

2-Hydroxypropyl-β-cyclodextrin (HPβCD) as a potential therapeutic agent for breast cancer

ST Saha, N Abdulla, T Zininga, A Shonhai, R Wadee… - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is a global burden with the most severe subtype being triple
negative breast cancer (TNBC). Despite advances in conventional therapies, treatment for …

Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis

PW Zhao, JX Cui, XM Wang - The Pharmacogenomics Journal, 2024 - nature.com
Objective To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-
negative breast cancer (TNBC) cells, focusing on its interaction with the …

Hesperidin PLGA nanoparticles potentiate the efficacy of aPD-1 in treating triple negative breast cancer by regulating CCL2 and ADPN expression in cancer …

N Luo, L Ma, N Ma, J Wei, H Zhang, W Jin, Y Li… - International …, 2024 - Elsevier
Triple negative breast cancer (TNBC) represents a heterogeneous subtype of breast cancer
characterized by an unfavorable prognosis due to its aggressive biology. Cancer-associated …