Microtubules provide long tracks along which a broad range of organelles and vesicles are
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Tau is an intrinsically disordered protein, which diffuses on microtubules. In
neurodegenerative diseases, collectively termed tauopathies, malfunction of tau and its …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such
as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

The proper organization of the microtubule-based mitotic spindle is proposed to depend on
nanometer-sized motor proteins generating forces that scale with a micron-sized geometric …

A eukaryotic cell is a microscopic world within which efficient material transport is essential.
Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment …