Autophagy and DNA repair are biological processes vital for cellular homeostasis
maintenance and when dysfunctional, they lead to several human disorders including …

Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant
organism ever known, and can tolerate extreme environments such as ionizing radiation …

Although oxygen (O2) is essential for aerobic life, it can also be an important source of
cellular damage. Supra-physiological levels of O2 determine toxicity due to exacerbated …

Oxidative DNA damage‐related diseases, such as incurable inflammation, malignant
tumors, and age‐related disorders, present significant challenges in modern medicine due …

Renal ischemia–reperfusion injury (IRI) is mainly responsible for acute kidney injury for
which there is no effective therapy. Accumulating evidence has indicated the important role …

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of
cellular components, including protein aggregates, damaged organelles (such as …

Ventilation with gases containing enhanced fractions of oxygen is the cornerstone of therapy
for patients with hypoxia and acute respiratory distress syndrome. Yet, hyperoxia treatment …

In recent years, a considerable correlation has emerged between autophagy and genome
integrity. A range of mechanisms appear to be involved where autophagy participates in …

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and
mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group …

DNA glycosylases are enzymes that initiate the base excision repair pathway, a major
biochemical process that protects the genomes of all living organisms from intrinsically and …