Emerging role of hepatic ketogenesis in fatty liver disease
RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …
Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending?
Nonalcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver dysfunctions
and it is predicted to become the primary cause of liver failure and hepatocellular carcinoma …
and it is predicted to become the primary cause of liver failure and hepatocellular carcinoma …
[HTML][HTML] Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis
LY Beppu, RGR Mooli, X Qu, GJ Marrero, CA Finley… - JCI insight, 2021 - ncbi.nlm.nih.gov
Abstract Interleukin-10 (IL-10) is a critical cytokine used by immune cells to suppress
inflammation. Paradoxically, immune cell–derived IL-10 can drive insulin resistance in …
inflammation. Paradoxically, immune cell–derived IL-10 can drive insulin resistance in …
Mitochondrial regulation and white adipose tissue homeostasis
The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …
[HTML][HTML] Oxidative stress and redox signaling in the pathophysiology of liver diseases
The increased production of derivatives of molecular oxygen and nitrogen in the form of
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …
Remodeling of mitochondrial plasticity: the key switch from NAFLD/NASH to HCC
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
the third-leading cause of cancer-related mortality. Currently, the global burden of …
the third-leading cause of cancer-related mortality. Currently, the global burden of …
[HTML][HTML] Sesamol promotes browning of white adipocytes to ameliorate obesity by inducing mitochondrial biogenesis and inhibition mitophagy via β3-AR/PKA …
C Lin, J Chen, M Hu, W Zheng, Z Song… - Food & Nutrition …, 2021 - ncbi.nlm.nih.gov
Background Obesity is defined as an imbalance between energy intake and expenditure,
and it is a serious risk factor of non-communicable diseases. Recently many studies have …
and it is a serious risk factor of non-communicable diseases. Recently many studies have …
[HTML][HTML] Growth hormone induces transforming growth factor-β1 in podocytes: Implications in podocytopathy and proteinuria
Pituitary growth hormone (GH) is essential for growth, metabolism, and renal function.
Overactive GH signaling is associated with impaired kidney function. Glomerular podocytes …
Overactive GH signaling is associated with impaired kidney function. Glomerular podocytes …
[HTML][HTML] Regulation of adipose thermogenesis and its critical role in glucose and lipid metabolism
L Wang, Y Qiu, H Gu, M Gan, Y Zhu, K Zhu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The function of the adipose tissue is influenced by complex interactions between genetics,
epigenetics, and the environment, and its dysfunction can cause a variety of metabolic …
epigenetics, and the environment, and its dysfunction can cause a variety of metabolic …
Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets
Cardiometabolic diseases present an escalating global health and economic burden. Such
a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and …
a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and …