Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …

Metastatic cancer cells dynamically adjust their shape to adhere, invade, migrate, and
expand to generate secondary tumors. Inherent to these processes is the constant assembly …

Invadosomes and caveolae are mechanosensitive structures that are implicated in
metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix …

Background Tumor cells are known to release large numbers of exosomes containing active
substances that participate in cancer progression. Abnormally expressed long noncoding …

Scaffold proteins are typically thought of as multi-domain “bridging molecules.” They serve
as crucial regulators of key signaling events by simultaneously binding multiple participants …

Invadopodia formation is regulated by Rho GTPases. However, the molecular mechanisms
that control Rho GTPase signaling at invadopodia remain poorly understood. Here, we have …

Under normal conditions, the cellular microenvironment is optimized for the proper
functioning of the tissues and organs. Cells recognize and communicate with the …

Invadopodia, being actin-rich membrane protrusions, play a vital role in tumor cell invasion
and metastasis. Our previous studies have revealed some functions of the DOC-2/DAB2 …

Abstract Yes-associated protein 1 (YAP1), a central component of the Hippo pathway, plays
an important role in tumor metastasis; however, the underlying mechanism remains to be …