Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very
rich pharmacology. Some of their modulators, including benzodiazepines and general …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

Publisher Summary The functional properties of ion channels, such as gating, ion selectivity,
single-channel conductance, multi-ion occupancy, transient blocking, desensitization, and …

The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

Glycinergic synapses play a central role in motor control and pain processing in the central
nervous system. Glycine receptors (GlyRs) are key players in mediating fast inhibitory …