Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Protein design has come of age, but how will it mature? In the 1980s and the 1990s, the
primary motivation for de novo protein design was to test our understanding of the …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

Mitophagy, the elimination of mitochondria via the autophagy‐lysosome pathway, is
essential for the maintenance of cellular homeostasis. The best characterised mitophagy …

Intermediate filaments (IFs) are essential constituents of the metazoan cytoskeleton. A vast
family of cytoplasmic IF proteins are capable of self-assembly from soluble tetrameric …

Motivation Protein–protein interactions are central to all biological processes. One frequently
observed mode of such interactions is the α-helical coiled coil (CC). Thus, an ability to …

In many organs, small openings across capillary endothelial cells (ECs) allow the diffusion
of low–molecular weight compounds and small proteins between the blood and tissue …

Septins are cytoskeletal proteins conserved from algae and protists to mammals. A unique
feature of septins is their presence as heteromeric complexes that polymerize into filaments …

Given the role of intermediate filaments (IFs) in normal cell physiology and scores of IF-
linked diseases, the importance of understanding their molecular structure is beyond doubt …

Intermediate filaments (IFs) form an essential part of the metazoan cytoskeleton. Despite a
long history of research, a proper understanding of their molecular architecture and …