The remarkable processes that characterize living organisms, such as motility, self-healing
and reproduction, are fuelled by a continuous injection of energy at the microscale. The field …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Intestinal organoids derived from single cells undergo complex crypt–villus patterning and
morphogenesis. However, the nature and coordination of the underlying forces remains …

Fundamental biological processes are carried out by curved epithelial sheets that enclose a
pressurized lumen. How these sheets develop and withstand three-dimensional …

Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …

Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

The early development of many organisms involves the folding of cell monolayers, but this
behaviour is difficult to reproduce in vitro; therefore, both mechanistic causes and effects of …

Actomyosin machinery endows cells with contractility at a single-cell level. However, within a
monolayer, cells can be contractile or extensile based on the direction of pushing or pulling …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Regional phenotypic and functional differences in the retinal pigment epithelium (RPE)
monolayer have been suggested to account for regional susceptibility in ocular diseases …