Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Genome sequencing projects have provided researchers with a complete inventory of the
predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of …

The role of membrane progesterone receptors (mPRs), which belong to the progestin and
adipoQ receptor (PAQR) family, in mediating rapid, nongenomic (non-classical) …

The dynamin-related guanosine triphosphatase Drp1 mediates the division of mitochondria
and peroxisomes. To understand the in vivo function of Drp1, complete and tissue-specific …

Diverse functions of eukaryotic cells are optimized by organization of compatible chemistries
into distinct compartments defined by the structures of lipid-containing membranes …

Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Background Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding
protein inducing dimerization with cytochrome P450, which mediates chemoresistance …

Rapid effects of steroid hormones result from the actions of specific receptors localized most
often to the plasma membrane. Fast-acting membrane-initiated steroid signaling (MISS) …

Progesterone-receptor membrane component 1 (PGRMC1/Sigma-2 receptor) is a haem-
containing protein that interacts with epidermal growth factor receptor (EGFR) and …