In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

Sphere-forming assays have been widely used to retrospectively identify stem cells based
on their reported capacity to evaluate self-renewal and differentiation at the single-cell level …

Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its
molecular mechanisms are not fully understood. Here, we report that FoxM1 is a …

Cancer Stem Cells (CSCs) are a sub-population of cells, identified in most tumors,
responsible for the initiation, recurrence, metastatic potential, and resistance of different …

Colony-forming units–fibroblast (CFU-Fs), analogous to those giving rise to bone marrow
(BM) mesenchymal stem cells (MSCs), are present in many organs, although the …

The intermediate filament protein, nestin, is a widely employed marker of multipotent neural
stem cells (NSCs). Recent in vitro studies have implicated nestin in a number of cellular …

Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in
the normal brain, and is common in malignant brain tumors. We examined the effects of …

Neural stem cells (NSCs) are present not only during the embryonic development but also in
the adult brain of all mammalian species, including humans. Stem cell niche architecture in …

Neural stem cells (NSCs) can be experimentally derived or induced from different sources,
and the NSC systems generated so far are promising tools for basic research and …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …