Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …

Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

▪ Abstract Apoptosis, a physiological process for killing cells, is critical for the normal
development and function of multicellular organisms. Abnormalities in cell death control can …

Studies performed over the past five years have demonstrated that there are two major cell-
intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death …

Each day, approximately 50 to 70 billion cells perish in the average adult because of
programmed cell death (PCD). Cell death in self-renewing tissues, such as the skin, gut, and …

A large number of correlative studies have established that the activation of the unfolded
protein response (UPR) alters the cell's sensitivity to chemotherapeutic agents. Although the …

Anticancer treatment using cytotoxic drugs is considered to mediate cell death by activating
key elements of the apoptosis program and the cellular stress response. While proteolytic …

Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and-
independent manner during apoptosis. Here, we report that the gene for caspase 8 is …

The p53 tumor suppressor gene is critically involved in cell cycle regulation, DNA repair, and
programmed cell death. Several lines of evidence suggest that p53 death signals lead to …