Functions of BLM helicase in cells: is it acting like a double-edged sword?
DNA damage repair response is an important biological process involved in maintaining the
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …
Bloom syndrome and the underlying causes of genetic instability
M Ababou - Molecular genetics and metabolism, 2021 - Elsevier
Autosomal hereditary recessive diseases characterized by genetic instability are often
associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with< …
associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with< …
Oxidative damage induces a vacancy G-quadruplex that binds guanine metabolites: solution structure of a cGMP fill-in vacancy G-quadruplex in the oxidized BLM …
KB Wang, Y Liu, Y Li, J Dickerhoff, J Li… - Journal of the …, 2022 - ACS Publications
Guanine (G)-oxidation to 8-oxo-7, 8-dihydroguanine (OG) by reactive oxygen species in
genomic DNA has been implicated with various human diseases. G-quadruplex (G4) …
genomic DNA has been implicated with various human diseases. G-quadruplex (G4) …
Design, synthesis, and evaluation of new quinazolinone derivatives that inhibit bloom syndrome protein (BLM) helicase, trigger DNA damage at the telomere region …
CX Wang, ZL Zhang, QK Yin, JL Tu… - Journal of Medicinal …, 2020 - ACS Publications
DNA damage response (DDR) pathways are crucial for the survival of cancer cells and are
attractive targets for cancer therapy. Bloom syndrome protein (BLM) is a DNA helicase that …
attractive targets for cancer therapy. Bloom syndrome protein (BLM) is a DNA helicase that …
Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach
The BLM helicase protein plays a vital role in DNA replication and the maintenance of
genomic integrity. Variation in the BLM helicase gene resulted in defects in the DNA repair …
genomic integrity. Variation in the BLM helicase gene resulted in defects in the DNA repair …
Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers
AR Green, MA Aleskandarany, R Ali, EG Hodgson… - Cancer immunology …, 2017 - AACR
Impaired DNA repair drives mutagenicity, which increases neoantigen load and
immunogenicity. We investigated the expression of proteins involved in the DNA damage …
immunogenicity. We investigated the expression of proteins involved in the DNA damage …
DNA damage repair in breast cancer and its therapeutic implications
The DNA damage response (DDR) involves the activation of numerous cellular activities that
repair DNA lesions and maintain genomic integrity, and is critical in preventing …
repair DNA lesions and maintain genomic integrity, and is critical in preventing …
USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM
C Wu, Y Chang, J Chen, Y Su, L Li, Y Chen… - Nucleic acids …, 2021 - academic.oup.com
The human RecQ helicase BLM is involved in the DNA damage response, DNA metabolism,
and genetic stability. Loss of function mutations in BLM cause the genetic instability/cancer …
and genetic stability. Loss of function mutations in BLM cause the genetic instability/cancer …
Discovery of isaindigotone derivatives as novel bloom's syndrome protein (BLM) helicase inhibitors that disrupt the BLM/DNA interactions and regulate the …
QK Yin, CX Wang, YQ Wang, QL Guo… - Journal of Medicinal …, 2019 - ACS Publications
Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an
attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a …
attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a …
Synthetic lethal interactions of RECQ helicases
DNA helicases have risen to the forefront as genome caretakers. Their prominent roles in
chromosomal stability are demonstrated by the linkage of mutations in helicase genes to …
chromosomal stability are demonstrated by the linkage of mutations in helicase genes to …