Splenic marginal zone lymphoma: from genetics to management

L Arcaini, D Rossi, M Paulli - … Journal of the American Society of …, 2016 - ashpublications.org
Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy involving the spleen,
bone marrow, and frequently the blood. SMZL lymphomagenesis involves antigen and/or …

Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential

BK Roberts, G Collado, BJ Barnes - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Canonically, the transcription factor interferon regulatory factor 5 (IRF5) is a key mediator of
innate and adaptive immunity downstream of pathogen recognition receptors such as Toll …

KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype

A Clipson, M Wang, L De Leval, M Ashton-Key… - Leukemia, 2015 - nature.com
To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed
whole exome sequencing of 16 cases and identified novel recurrent inactivating mutations …

Genetics and prognostication in splenic marginal zone lymphoma: revelations from deep sequencing

M Parry, MJJ Rose-Zerilli, V Ljungström, J Gibson… - Clinical Cancer …, 2015 - AACR
Purpose: Mounting evidence supports the clinical significance of gene mutations and
immunogenetic features in common mature B-cell malignancies. Experimental Design: We …

Emerging role of infectious etiologies in the pathogenesis of marginal zone B-cell lymphomas

E Zucca, F Bertoni, B Vannata, F Cavalli - Clinical cancer research, 2014 - AACR
Extranodal marginal zone B-cell lymphomas of the mucosa-associated lymphoid tissue
(MALT) arise from lymphoid populations that are induced by chronic inflammation in …

Interferon regulatory factor 1 inactivation in human cancer

K Alsamman, OS El-Masry - Bioscience Reports, 2018 - portlandpress.com
Interferon regulatory factors (IRFs) are a group of closely related proteins collectively
referred to as the IRF family. Members of this family were originally recognized for their roles …

Differential p53-mediated cellular responses to DNA-damaging therapeutic agents

L Carlsen, WS El-Deiry - International Journal of Molecular Sciences, 2021 - mdpi.com
The gene TP53, which encodes the tumor suppressor protein p53, is mutated in about 50%
of cancers. In response to cell stressors like DNA damage and after treatment with DNA …

Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma

M Parry, MJJ Rose-Zerilli, J Gibson, S Ennis… - PloS one, 2013 - journals.plos.org
The pathogenesis of splenic marginal zone lymphoma (SMZL) remains largely unknown.
Recent high-throughput sequencing studies have identified recurrent mutations in key …

DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features

AJ Arribas, A Rinaldi, AA Mensah… - Blood, The Journal …, 2015 - ashpublications.org
Splenic marginal zone lymphoma is a rare lymphoma. Loss of 7q31 and somatic mutations
affecting the NOTCH2 and KLF2 genes are the commonest genomic aberrations. Epigenetic …

Unraveling the genetics of transformed splenic marginal zone lymphoma

M Grau, C López, A Navarro, G Frigola… - Blood …, 2023 - ashpublications.org
The genetic mechanisms associated with splenic marginal zone lymphoma (SMZL)
transformation are not well defined. We studied 41 patients with SMZL that eventually …