Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …

Cytotoxic T lymphocytes (CTLs) are critical in the elimination of infected or malignant cells
and are emerging as a major therapeutic target. How CTLs recognize and kill harmful cells …

In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …

Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T
cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss …

Malignancy can be suppressed by the immune system in a process termed
immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous …

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …

SARS-CoV-2 is a single-stranded RNA virus that causes COVID-19. Given its acute and
often self-limiting course, it is likely that components of the innate immune system play a …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search
or following signals by other leukocytes. Here, we reveal independent emergent behaviour …