Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …

Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

Purpose Mammographic breast density is an established risk marker for breast cancer and
is visually assessed by radiologists in routine mammogram image reading, using four …

Breast density, as assessed by mammography, reflects breast tissue composition. Breast
epithelium and stroma attenuate x-rays more than fat and thus appear light on …

Women with dense breasts have an increased lifetime risk of malignancy that has been
attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and …

There has been considerable recent interest in the genetic, biological and epidemiological
basis of mammographic density (MD), and the search for causative links between MD and …

One of the most important risk factors for breast cancer is family history of the disease,
indicating that genetic factors are important determinants of breast cancer risk. A number of …

Mammographic density reflects the amount of stromal and epithelial tissues in relation to
adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the …

Background Mammographic density is a heritable quantitative trait and is a strong risk factor
for breast cancer in middle-aged and older women. However, little is known about the …

Today, breast cancer is the most commonly occurring cancer among women. It accounts for
22% of all female cancers and the estimated annual incidence of breast cancer worldwide is …