Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Diabetic retinopathy (DR) is the most common microvascular complication in diabetic
patients and one of the main causes of acquired blindness in the world. From the 90s until …

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes
appear to share common mechanisms of neuronal cellular dysfunction, including …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …

The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …

The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …

Oxidative stress figures prominently in retinal diseases, including diabetic retinopathy, and
glaucoma. Ligands for σ1R, a unique transmembrane protein localized to the endoplasmic …

The effects of imeglimin, a novel antidiabetes agent, on β-cell function remain unclear. Here,
we unveiled the impact of imeglimin on β-cell survival. Treatment with imeglimin augmented …