Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …

Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …

Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination,
resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular …

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

Cancer cells grow in an environment comprised of multiple components that support tumor
growth and contribute to therapy resistance. Major cell types in the tumor microenvironment …

Proteases play a crucial role in the progression and metastasis of ovarian cancer.
Pericellular protein degradation and fragmentation along with remodeling of the …

Dissemination of ovarian cancer cells can lead to inoperable metastatic lesions in the bowel
and omentum that cause patient death. Here we show that LRRC15, a type-I 15-leucine–rich …

Abstract microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which
structurally consist of 19–22 nucleotides in length and functionally act as one of the main …

Although most ovarian cancer patients are highly responsive to chemotherapy, they
frequently present with recurrent metastatic lesions that result in poor overall survival, a …