Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced
chronic fibrosis is described as cirrhosis with a loss of architecture and attendant functional …

Animal models are crucial for improving our understanding of human pathogenesis,
enabling researchers to identify therapeutic targets and test novel drugs. In the current …

In most vertebrates, the liver produces bile that is necessary to emulsify absorbed fats and
enable the digestion of lipids in the small intestine as well as to excrete bilirubin and other …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Several studies have characterized the cellular and molecular mechanisms of hepatocyte
injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs …

Chapter 1: Introduction--Chapter 2: Integumentary System----Skin and subcutaneous tissue--
Chapter 3: Mammary Gland--Chapter 4: Haemopoietic and Lymphatic Systems …

Chronic liver diseases are frequent and potentially life threatening for humans. The
underlying etiologies are diverse, ranging from viral infections, autoimmune disorders, and …

Liver fibrosis occurs as a wound-healing response to chronic hepatic injuries irrespective of
the underlying etiology and may progress to life-threatening cirrhosis. Here we show that …

Background: Angiotensin converting enzyme (ACE) 2 is a recently identified homologue of
ACE that may counterregulate the actions of angiotensin (Ang) II by facilitating its breakdown …

Background & Aims: The farnesoid X receptor (FXR) is an endogenous sensor for bile acids
and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene …