Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders.
However, it is unclear how aging interacts with genetic predispositions to promote …

Non-coding regions amplified beyond oncogene borders have largely been ignored. Using
a computational approach, we find signatures of significant co-amplification of non-coding …

We report the results of whole-genome and transcriptome sequencing of tumor and adjacent
normal tissue samples from 17 patients with non-small cell lung carcinoma (NSCLC). We …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high …

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA
repair. Here, we find that DNA damage triggers a critical block in glutamine metabolism …

Lineage-survival oncogenes are activated by somatic DNA alterations in cancers arising
from the cell lineages in which these genes play a role in normal development,. Here we …

We screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using
a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 …

Despite the high prevalence and poor outcome of patients with metastatic lung cancer the
mechanisms of tumour progression and metastasis remain largely uncharacterized. Here we …