Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam

DP McManus, DJ Gray, Y Li, Z Feng… - Clinical microbiology …, 2010 - Am Soc Microbiol
The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in
China has invoked considerable global concern. The TGD will result in changes in the water …

HDAC inhibitors in parasitic diseases

KT Andrews, A Haque, MK Jones - Immunology and cell …, 2012 - Wiley Online Library
Parasitic diseases cause significant global morbidity and mortality, particularly in
underdeveloped regions of the world. Malaria alone causes∼ 800 000 deaths each year …

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

GJ Crowther, D Shanmugam, SJ Carmona… - PLoS neglected …, 2010 - journals.plos.org
Background The increased sequencing of pathogen genomes and the subsequent
availability of genome-scale functional datasets are expected to guide the experimental …

TDR Targets: a chemogenomics resource for neglected diseases

MP Magariños, SJ Carmona, GJ Crowther… - Nucleic acids …, 2012 - academic.oup.com
Abstract The TDR Targets Database (http://tdrtargets. org) has been designed and
developed as an online resource to facilitate the rapid identification and prioritization of …

A comparative proteomic study of the undeveloped and developed Schistosoma mansoni egg and its contents: the miracidium, hatch fluid and secretions

W Mathieson, RA Wilson - International journal for parasitology, 2010 - Elsevier
The schistosome egg is the key agent responsible both for transmission of the parasite from
human to molluscan host, and is the primary cause of pathogenesis in schistosomiasis …

A wake up call for urinary schistosomiasis: reconciling research effort with public health importance

D Rollinson - Parasitology, 2009 - cambridge.org
This review considers the current status of urinary schistosomiasis, caused by infection with
Schistosoma haematobium, and argues that greater research effort and focus are needed to …

Exposed proteins of the Schistosoma japonicum tegument

J Mulvenna, L Moertel, MK Jones, S Nawaratna… - International journal for …, 2010 - Elsevier
The ability of the mammalian blood fluke Schistosoma japonicum to survive in the
inhospitable environment of the mammalian bloodstream can be attributed, at least in part …

Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction

ZG Han, PJ Brindley, SY Wang… - Annual review of …, 2009 - annualreviews.org
Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S.
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening

S Štefanić, J Dvořák, M Horn, S Braschi… - PLoS neglected …, 2010 - journals.plos.org
Background The possible emergence of resistance to the only available drug for
schistosomiasis spurs drug discovery that has been recently incentivized by the availability …

Elucidating the transcriptome of Fasciola hepatica—a key to fundamental and biotechnological discoveries for a neglected parasite

ND Young, RS Hall, AR Jex, C Cantacessi… - Biotechnology …, 2010 - Elsevier
Liver flukes of animals are parasitic flatworms (Platyhelminthes: Digenea) of major
socioeconomic importance in many countries. Key representatives, such as Fasciola …