[HTML][HTML] Melatonin synthesis and function: evolutionary history in animals and plants

D Zhao, Y Yu, Z Zhao, R Sharma… - Frontiers in …, 2019 - frontiersin.org
Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …

Anti-inflammatory effects of Melatonin: A mechanistic review

SM Nabavi, SF Nabavi, A Sureda, J Xiao… - Critical reviews in …, 2019 - Taylor & Francis
Abstract N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by
plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In …

Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization

B Farhood, NH Goradel, K Mortezaee… - Clinical and …, 2019 - Springer
It is estimated that more than half of cancer patients undergo radiotherapy during the course
of their treatment. Despite its beneficial therapeutic effects on tumor cells, exposure to high …

Radiation-induced inflammation and autoimmune diseases

R Yahyapour, P Amini, S Rezapour, M Cheki… - Military Medical …, 2018 - Springer
Currently, ionizing radiation (IR) plays a key role in the agricultural and medical industry,
while accidental exposure resulting from leakage of radioactive sources or radiological …

Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications

M Najafi, E Motevaseli, A Shirazi, G Geraily… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation

HH Aminjan, SR Abtahi, E Hazrati, M Chamanara… - Life Sciences, 2019 - Elsevier
Aims Poisoning with aluminium phosphide (AlP) commonly has a high rate of mortality and
morbidities. Phosphine gas is the main cause of AlP poisoning that has deleterious effect on …

[HTML][HTML] Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens

Y Liu, Y Jia, K Yang, Z Tong, J Shi, R Li, X Xiao… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Emergence, prevalence and widely spread of plasmid-mediated colistin
resistance in Enterobacteriaceae strongly impairs the clinical efficacy of colistin against life …

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

M Ashrafizadeh, S Tavakol, Z Ahmadi… - Phytotherapy …, 2020 - Wiley Online Library
Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and
autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial …

Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics

R Yahyapour, E Motevaseli, A Rezaeyan… - Clinical and …, 2018 - Springer
Every year, millions of cancer patients undergo radiation therapy for treating and destroying
abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation …

[HTML][HTML] Radiation-induced PD-L1 expression in tumor and its microenvironment facilitates cancer-immune escape: a narrative review

NH Wang, Z Lei, HN Yang, Z Tang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Methods We performed a narrative review of the literature in the PubMed database. The
research string comprised various combinations of “radiotherapy”,“programmed death …