The role of exosomal microRNAs and oxidative stress in neurodegenerative diseases

X Wang, Y Zhou, Q Gao, D Ping, Y Wang… - Oxidative medicine …, 2020 - Wiley Online Library
Neurodegenerative diseases including Alzheimer's disease and Parkinson's disease are
aging‐associated diseases with irreversible damage of brain tissue. Oxidative stress is …

Circulating exosomal miRNA as diagnostic biomarkers of neurodegenerative diseases

L Wang, L Zhang - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases (NDDs) are a group of diseases caused by chronic and
progressive degeneration of neural tissue. The main pathological manifestations are …

Mesenchymal stromal cell therapies for neurodegenerative diseases

NP Staff, DT Jones, W Singer - Mayo Clinic Proceedings, 2019 - Elsevier
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

X Paez-Colasante, C Figueroa-Romero… - Nature Reviews …, 2015 - nature.com
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor
neurons, which results in weakness and atrophy of voluntary skeletal muscles. Treatments …

Dysregulated mi RNA biogenesis downstream of cellular stress and ALS‐causing mutations: a new mechanism for ALS

A Emde, C Eitan, LL Liou, RT Libby, N Rivkin… - The EMBO …, 2015 - embopress.org
Interest in RNA dysfunction in amyotrophic lateral sclerosis (ALS) recently aroused upon
discovering causative mutations in RNA‐binding protein genes. Here, we show that …

Biomarkers in motor neuron disease: a state of the art review

NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Small non-coding RNAs: new class of biomarkers and potential therapeutic targets in neurodegenerative disease

CN Watson, A Belli, V Di Pietro - Frontiers in genetics, 2019 - frontiersin.org
Neurodegenerative diseases (NDs) are becoming increasingly prevalent in the world, with
an aging population. In the last few decades, due to the devastating nature of these …

Stress-induced changes in miRNA biogenesis and functioning

M Olejniczak, A Kotowska-Zimmer… - Cellular and molecular life …, 2018 - Springer
MicroRNAs (miRNAs) are small, noncoding RNAs that play key roles in the regulation of
cellular homeostasis in eukaryotic organisms. There is emerging evidence that some of …

[HTML][HTML] Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS)

R Waller, EF Goodall, M Milo, J Cooper-Knock… - Neurobiology of …, 2017 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative condition characterized by
loss of motor neurones and progressive muscle wasting. There is no diagnostic test for ALS …

RNA metabolism in neurodegenerative disease

EY Liu, CP Cali, EB Lee - Disease models & mechanisms, 2017 - journals.biologists.com
Aging-related neurodegenerative diseases are progressive and fatal neurological diseases
that are characterized by irreversible neuron loss and gliosis. With a growing population of …