Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

Inter-individual variability in perception, thought and action is frequently treated as a source
of'noise'in scientific investigations of the neural mechanisms that underlie these processes …

Since living in cities is associated with an increased risk for mental disorders such as anxiety
disorders, depression, and schizophrenia, it is essential to understand how exposure to …

The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …

Schizophrenia has been conceived as a disorder of brain connectivity, but it is unclear how
this network phenotype is related to the underlying genetics. We used morphometric …

Subcortical structures, which include the basal ganglia and parts of the limbic system, have
key roles in learning, motor control and emotion, but also contribute to higher-order …

Although structural brain alterations in schizophrenia have been demonstrated extensively,
their quantitative distribution has not been studied over the last 14 years despite advances …

More than half of the world's population now lives in cities, making the creation of a healthy
urban environment a major policy priority. Cities have both health risks and benefits, but …

Importance Schizophrenia is associated with alterations in mean regional brain volumes.
However, it is not known whether the clinical heterogeneity seen in the disorder is reflected …

Context Antipsychotic treatment is the first-line treatment option for schizophrenia. Individual
studies suggested they can significantly affect brain structure and account for progressive …