Dopaminergic perturbation in the aetiology of neurodevelopmental disorders

OK Ijomone, RS Oria, OM Ijomone, M Aschner… - Molecular …, 2024 - Springer
Brain development may be influenced by both genetic and environmental factors, with
potential consequences that may last through the lifespan. Alterations during neurogenesis …

Role of the dopaminergic system in the striatum and its association with functional recovery or rehabilitation after brain injury

A Verduzco-Mendoza, P Carrillo-Mora… - Frontiers in …, 2021 - frontiersin.org
Disabilities are estimated to occur in approximately 2% of survivors of traumatic brain injury
(TBI) worldwide, and disability may persist even decades after brain injury. Facilitation or …

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF-α mediated activation of NLRP3 inflammasome

VV Gopnar, D Rakshit, M Bandakinda, U Kulhari… - Neurotoxicology, 2023 - Elsevier
Groundwater is considered safe, however, the occurrence of contaminants like arsenic and
fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and …

Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt …

A Mishra, S Singh, V Tiwari, S Chaturvedi… - Neurochemistry …, 2019 - Elsevier
Nigral dopaminergic (DAergic) cell degeneration and depletion of dopamine
neurotransmitter in the midbrain are cardinal features of Parkinson's disease (PD) …

Dopaminergic modulation of forced running performance in adolescent rats: role of striatal D1 and extra-striatal D2 dopamine receptors

A Toval, D Garrigos, Y Kutsenko, M Popović… - Molecular …, 2021 - Springer
Improving exercise capacity during adolescence impacts positively on cognitive and motor
functions. However, the neural mechanisms contributing to enhance physical performance …

Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase‐1 improves cognitive performance

A Pekcec, N Schülert, B Stierstorfer… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Insufficient prefrontal dopamine 1 (D1) receptor signalling has
been linked to cognitive dysfunction in several psychiatric conditions. Because the PDE1 …

Dopamine D2-subtype receptors outside the blood-brain barrier mediate enhancement of mesolimbic dopamine release and conditioned place preference by …

JD Obray, CA Small, EK Baldwin, EY Jang… - Frontiers in Cellular …, 2022 - frontiersin.org
Dopamine (DA) is a cell-signaling molecule that does not readily cross the blood-brain
barrier. Despite this, peripherally administered DA enhances DA levels in the nucleus …

Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid‐onset parkinsonian motor phenotype in mice

C del Agua Villa, M Atudorei… - European Journal of …, 2024 - Wiley Online Library
Dopaminergic nigrostriatal denervation in Parkinson's disease (PD) disrupts the functional
balance between striatal projecting neurons, leading to aberrant activity in the cortico‐basal …

Balance alterations and reduction of pedunculopontine cholinergic neurons in early stages of parkinsonism in middle-aged rats

TFO Dos Santos, ER Santos, JMM Bispo… - Experimental …, 2021 - Elsevier
The purpose of the present study was to investigate balance alterations and the possible
role of the cholinergic neurons in the pedunculopontine nucleus (PPN) in the early stages of …

The effects of intravermis cerebellar microinjections of dopaminergic agents in motor learning and aversive memory acquisition in mice

EM Guilherme, ACL Gianlorenço - Frontiers in Behavioral …, 2021 - frontiersin.org
The cerebellum receives dopaminergic innervation and expresses the five types of
described dopaminergic receptors. The cerebellar function involves both motor movement …