Quantum chemical calculations have been used in the development of synthetic
methodologies to analyze the reaction mechanisms of the developed reactions. Their ability …

Cyclic nitriles have a long and distinguished history as versatile synthetic intermediates. 1
The versatility stems from the nitrile's extremely high polar-inductive effect, 2 their excellent …

The mechanism by which zinc (II) catalyzes the union of an azide ion with organic nitriles to
form tetrazoles is investigated by means of density functional theory using the hybrid …

Woodward and Hoffman once jested that a very powerful Maxwell demon could seize a
molecule of cyclobutene at its methylene groups and tear it open in a disrotatory fashion to …

Benzyne-[2+ 2] cycloadditions with enamides are described. This effort led to the
development of a highly stereoselective tandem [2+ 2] cycloaddition− pericyclic ring …

Here, we document the reinvention of aryne chemistry with" old" o-diiodoarenes as aryne
progenitors. We have established a NaH-mediated activation strategy for the generation of …

To understand the torquoselectivity and the electronic effects of the Staudinger reaction, a
study using a combination of experiments and DFT calculations has been conducted for the …

The stereoselectivity of the Staudinger reactions involving monosubstituted ketenes with
electron acceptor substituents was investigated experimentally by determination of the …

Currently the theories to explain and predict the classification of the electronic
reorganization due to the torquoselectivity of a ring‐opening reaction cannot accommodate …

Thermal rearrangements of cyclobutenones give access to numerous ring systems and have
proven especially valuable for the de novo synthesis of quinones, benzoquinones, and …