One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

The corticospinal tract (CST) is the most important motor system in humans, yet robust
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Although a number of repair strategies have been shown to promote axon outgrowth
following neuronal injury in the mammalian CNS, it remains unclear whether regenerated …

A major hurdle for functional recovery after both spinal cord injury and cortical stroke is the
limited regrowth of the axons in the corticospinal tract (CST) that originate in the motor cortex …