This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Abstract Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two endogenous ligands that
belong to the opioid peptide family and have the highest affinity and selectivity for the µ …

Objective: Preclinical evidence indicates that gene transfer to the dorsal root ganglion using
replication‐defective herpes simplex virus (HSV)‐based vectors can reduce pain‐related …

Opioids acting at the mu opioid receptor (MOR) are the most effective analgesics, however
adverse side effects severely limit their use. Of particular importance, abuse liability results …

Chronic pain is a major health concern that affects millions of people. There are no
adequate long‐term therapies for chronic pain sufferers, leading to significant cost for both …

Gene transfer to the dorsal root ganglion using replication defective herpes simplex virus
(HSV)-based vectors reduces pain-related behaviors in rodent models having inflammatory …

Chronic pain is a major health concern affecting 80million Americans at some time in their
lives with significant associated morbidity and effects on individual quality of life. Chronic …

Chronic pain is a major health concern with up to 50% of patients finding little if any relief
following traditional pharmacotherapy. This review describes the treatment of chronic pain …

Purpose: In this study, we evaluated the analgesic potential of demethylating drugs on oral
cancer pain. Although demethylating drugs could affect expression of many genes, we …

Introduction Due to side effects of medications used for chronic pain, combination therapy
seems to be an appropriate solution for alleviation of chronic pain and reducing the side …