Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Telomere biology disorders are a complex set of illnesses defined by the presence of very
short telomeres. Individuals with classic dyskeratosis congenita have the most severe …

Despite major progress in defining the functional roles of genes, a complete understanding
of their influences is far from being realized, even in relatively simple organisms. A major …

Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to
identify genes and pathways that regulate telomere length. We found 72 genes that when …

Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …

Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death
in Japan. Previous studies indicated some genetic factors contributing to the development …

Telomeres protect the chromosome ends from degradation and play crucial roles in cellular
aging and disease. Recent studies have additionally found a correlation between …

Telomeres cap chromosome ends and are critical for genomic stability. Many telomere‐
associated proteins are important for telomere length maintenance. Recent genome‐wide …

Telomeres are structures composed of repetitive DNA and proteins that protect the
chromosomal ends in eukaryotic cells from fusion or degradation, thus contributing to …

Abstract In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase
and to “cap” chromosome ends. In temperature-sensitive cdc13-1 mutants telomeric DNA is …