A look at the importance of chirality in drug activity: Some significative examples

J Ceramella, D Iacopetta, A Franchini, M De Luca… - Applied Sciences, 2022 - mdpi.com
Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

Role of chirality in drugs: an overview

H Alkadi, R Jbeily - Infectious Disorders-Drug TargetsDisorders), 2018 - benthamdirect.com
Stereochemistry has occupied a great role in the manufacture and development of
pharmaceuticals. Chiral properties play an important role in the determination of …

Chiral ionic covalent organic framework as an enantioselective fluorescent sensor for phenylalaninol determination

JY Yue, LP Song, YH Shi, L Zhang, ZX Pan… - Analytical …, 2023 - ACS Publications
Phenylalaninol (PAL) is a significant chemical intermediate widely utilized in drug
development and chiral synthesis, for instance, as a reactant for bicyclic lactams and …

Development of a chiral supercritical fluid chromatography–Tandem mass spectrometry and reversed-phase liquid chromatography–Tandem mass spectrometry …

A Quaranta, B Zohrer, J Revol-Cavalier… - Analytical …, 2022 - ACS Publications
Octadecanoids are broadly defined as oxylipins (ie, lipid mediators) derived from 18-carbon
fatty acids. In contrast to the well-studied eicosanoids, there is a lack of analytical methods …

[图书][B] Handbook of research on medicinal chemistry: innovations and methodologies

DK Mahapatra, SK Bharti - 2017 - books.google.com
This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and
Methodologies, presents some of the latest advancements in the various fields of …

Astraodoric Acids A–D: New Lanostane Triterpenes from Edible Mushroom Astraeus odoratus and Their Anti-Mycobacterium tuberculosis H37Ra and Cytotoxic …

K Arpha, C Phosri, N Suwannasai… - Journal of agricultural …, 2012 - ACS Publications
Tuberculosis (TB) is one of the chronic infectious diseases caused by Mycobacterium
tuberculosis that causes about 2–3 million deaths per year. Isoniazid and rifampicin are …

Sieving nanometer enantiomers using bound states in the continuum from the metasurface

L Mao, P Cheng, K Liu, M Lian, T Cao - Nanoscale Advances, 2022 - pubs.rsc.org
Enantioseparation of chiral molecules is an important aspect of life sciences, chemical
syntheses, and physics. Yet, the prevailing chemical techniques are not effective. Recently …

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Č Ružena, V Jindra, H Renáta - Open Chemistry, 2020 - degruyter.com
Abstract β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic
drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary …

Synthesis of Novel Chiral Sulfonamide‐Bearing 1,2,4‐Triazole‐3‐thione Analogs Derived from D‐ and L‐Phenylalanine Esters as Potential Anti‐Influenza Agents

E Başaran, A Karaküçük‐Iyidoğan, D Schols… - Chirality, 2016 - Wiley Online Library
Abstract Novel enantiopure 1, 2, 4‐trizole‐3‐thiones containing a benzensulfonamide
moiety were synthesized via multistep reaction sequence starting with D‐phenylalanine …

Isopropyl 2-ethoxyacetate—an efficient acylating agent for lipase-catalyzed kinetic resolution of amines in batch and continuous-flow modes

M Oláh, Z Boros, G Hornyánszky, L Poppe - Tetrahedron, 2016 - Elsevier
Productivity [conversion (c) and specific reaction rate (r batch or r flow)] and enantiomer
selectivity [enantiomeric ratio (E) and enantiomeric excess (ee) of the products] of ethyl and …