International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …
and various drugs in development. Their diversity of structure and function reflects the …
New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders
G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
[HTML][HTML] Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors
RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter
protein function through modification of the amino acid content. The 5HT 2C serotonin …
protein function through modification of the amino acid content. The 5HT 2C serotonin …
Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties
The current dopamine (DA) hypothesis of schizophrenia postulates striatal
hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 …
hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 …
Mammalian conserved ADAR targets comprise only a small fragment of the human editosome
Background ADAR proteins are among the most extensively studied RNA binding proteins.
They bind to their target and deaminate specific adenosines to inosines. ADAR activity is …
They bind to their target and deaminate specific adenosines to inosines. ADAR activity is …
Potential impact of miR-137 and its targets in schizophrenia
C Wright, JA Turner, VD Calhoun… - Frontiers in …, 2013 - frontiersin.org
The significant impact of microRNAs (miRNAs) on disease pathology is becoming
increasingly evident. These small non-coding RNAs have the ability to post-transcriptionally …
increasingly evident. These small non-coding RNAs have the ability to post-transcriptionally …
A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment
This paper is a personal account on the discovery and characterization of the 5-HT 2C
receptor (first known as the 5-HT 1C receptor) over 30 years ago and how it translated into a …
receptor (first known as the 5-HT 1C receptor) over 30 years ago and how it translated into a …
Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits
Most human genetic studies assume that connections between genomic regions are
adequately captured by linkage disequilibrium (LD). LD reflects historical events that shaped …
adequately captured by linkage disequilibrium (LD). LD reflects historical events that shaped …
Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model
J Hebras, V Marty, J Personnaz, P Mercier, N Krogh… - elife, 2020 - elifesciences.org
SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its
ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I …
ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I …
Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence
NC Anastasio, SJ Stutz, RG Fox, RM Sears… - …, 2014 - nature.com
Relapse vulnerability in cocaine dependence is rooted in genetic and environmental
determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues …
determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues …