Regulation and function of Cdt1; a key factor in cell proliferation and genome stability

PN Pozo, JG Cook - Genes, 2016 - mdpi.com
Successful cell proliferation requires efficient and precise genome duplication followed by
accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is …

Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication

K Ramadan, S Halder, K Wiseman, B Vaz - Chromosoma, 2017 - Springer
Genome amplification (DNA synthesis) is one of the most demanding cellular processes in
all proliferative cells. The DNA replication machinery (also known as the replisome) …

miR‑221‑3p and miR‑15b‑5p promote cell proliferation and invasion by targeting Axin2 in liver cancer

Y Dong, N Zhang, S Zhao, X Chen… - Oncology …, 2019 - spandidos-publications.com
Globally, liver cancer has the third highest mortality rate among all types of cancer due to the
invasive and metastatic capacities of liver tumor cells. MicroRNA (miR) is a class of non …

The prognostic significance of Cdc6 and Cdt1 in breast cancer

R Mahadevappa, H Neves, SM Yuen, Y Bai… - Scientific reports, 2017 - nature.com
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes
correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and …

ILK expression in colorectal cancer is associated with EMT, cancer stem cell markers and chemoresistance

D Tsoumas, S Nikou, E Giannopoulou… - Cancer genomics & …, 2018 - cgp.iiarjournals.org
Background/Aim: Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are
critically implicated in cancer metastasis and chemoresistance. Herein, we investigated …

[HTML][HTML] Distinct diagnostic and prognostic values of minichromosome maintenance gene expression in patients with hepatocellular carcinoma

X Liao, X Liu, C Yang, X Wang, T Yu, C Han… - Journal of …, 2018 - ncbi.nlm.nih.gov
Background: The aim of the present study was to identify diagnostic and prognostic values of
minichromosome maintenance (MCM) gene expression in patients with hepatocellular …

[HTML][HTML] Expression of minichromosome maintenance proteins (MCM) and cancer prognosis: a meta-analysis

K Gou, J Liu, X Feng, H Li, Y Yuan, C Xing - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
Minichromosome maintenance proteins (MCM) played a critical role in replication and cell
cycle progression. However, their prognostic roles in cancer remain controversial. Therefore …

[PDF][PDF] RETRACTED ARTICLE: miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a …

F Li, F Wang, C Zhu, Q Wei, T Zhang… - International journal of …, 2018 - Taylor & Francis
Li F, Wang F, Zhu C, Wei Q, Zhang T, Zhou YL. Int J Nanomedicine. 2018; 13: 2295–2307.
The Editor and Publisher of International Journal of Nanomedicine wish to retract the …

LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance

H Aggelou, P Chadla, S Nikou, S Karteri, I Maroulis… - Virchows Archiv, 2018 - Springer
Cofilin phospho-regulation is important for actin filament turnover and is implicated in
cancer. Phosphorylation of cofilin is mediated by LIM kinases (LIMKs) and …

DNA replication licensing proteins: Saints and sinners in cancer

MJ Mughal, R Mahadevappa, HF Kwok - Seminars in Cancer Biology, 2019 - Elsevier
DNA replication is all-or-none process in the cell, meaning, once the DNA replication begins
it proceeds to completion. Hence, to achieve maximum control of DNA replication, eukaryotic …