The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …

The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …

Abstract Background The LIFE-Adult-Study is a population-based cohort study, which has
recently completed the baseline examination of 10,000 randomly selected participants from …

Formalin-fixed and paraffin-embedded (FFPE) tissue specimens are the gold standard for
histological examination, and they provide valuable molecular information in tissue-based …

Metabolomics is a truly interdisciplinary field of science, which combines analytical
chemistry, platform technology, mass spectrometry, and NMR spectroscopy with …

The LIFE Child study is a large population-based longitudinal childhood cohort study
conducted in the city of Leipzig, Germany. As a part of LIFE, a research project conducted at …

Nutritional metabolomics is rapidly maturing to use small-molecule chemical profiling to
support integration of diet and nutrition in complex biosystems research. These …

Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …

Metabolomics is an essential method to study the dynamic changes of metabolic networks
and products using modern analytical techniques, as well as reveal the life phenomena and …

Metabolomics is the comprehensive profiling of the small molecule composition of a
biological sample. Since metabolites are often the indirect products of gene expression, this …