▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …

▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal
anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin …

Prostaglandin endoperoxide H synthases (PGHSs) 1 catalyze the conversion of arachidonic
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991 …

Purpose. NSAIDs constitute an important class of drugs with therapeutic applications that
have spanned several centuries. Treatment of inflammatory conditions such as rheumatoid …

Cyclooxgenases are key enzymes of lipid signaling. They carry out the first step in the
production of prostaglandins, important mediators of inflammation, pain, cardiovascular …

Prostaglandins were discovered in human semen in 1930, but their low concentrations and
instability precluded identification for nearly 30 years (for a brief historical review, see Ref …

A variety of drugs inhibit the conversion of arachidonic acid to prostaglandin G 2 by the
cyclooxygenase (COX) activity of prostaglandin endoperoxide synthases. Several modes of …

Because of its structural similarity to polyunsaturated fatty acids, anandamide could serve as
substrate for enzymes such as lipoxygenases and cyclooxygenases, which metabolize …

Cyclooxygenases (COX) play an important role in lipid signaling by oxygenating arachidonic
acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases …