As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing
signals from the extracellular environment to the inside of the cell. They mediate the effects …

Modulators of the G protein-coupled A2A adenosine receptor (A2AAR) have been
considered promising agents to treat Parkinson's disease, inflammation, cancer, and central …

Since the identification of the SARS‐CoV‐2 virus as the causative agent of the current
COVID‐19 pandemic, considerable effort has been spent characterizing the interaction …

Limited chemical shift dispersion represents a significant barrier to studying multistate
equilibria of large membrane proteins by 19F NMR. We describe a novel monofluoroethyl …

Molecular dynamics (MD) simulations have made great contribution to revealing structural
and functional mechanisms for many biomolecular systems. However, how to identify …

Engineering G-protein-coupled receptors (GPCRs) for improved stability or altered function
is of great interest, as GPCRs consist of the largest protein family, are involved in many …

G protein-coupled receptors (GPCRs) are critical drug targets. GPCRs convey signals from
the extracellular to the intracellular environment through G proteins. Some ligands that bind …

The worldwide CoVid-19 pandemic has led to an unprecedented push across the whole of
the scientific community to develop a potent antiviral drug and vaccine as soon as possible …

Molecular modeling has contributed to drug discovery for purinergic GPCRs, including
adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and …