Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …

There is a number of systemic diseases affecting the cornea. These include endocrine
disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections …

Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most
frequent clinical condition affecting the human cornea, is a potentially sight-threatening …

The incidence of diabetes mellitus (DM) and its complications have increased considerably
worldwide. Diabetic keratopathy is the major complication of the cornea characterized by …

Diabetic keratopathy is characterized by impaired innervation of the cornea that leads to
decreased sensitivity, with resultant difficulties with epithelial wound healing. These …

Continuous replenishment of the corneal epithelium is pivotal for maintaining optical
transparency and achieving optimal visual perception. This dynamic process is driven by …

MicroRNAs (miRNAs) are single-strand endogenous and non-coding RNA molecules with a
length of about 22 nucleotides, which regulate genes expression, through modulating the …

Limbal epithelial stem cells (LESC) maintenance requires communication between stem
cells and neighboring stromal keratocytes. Extracellular vesicles (EVs) are important for …

Epithelial and stromal/mesenchymal limbal stem cells contribute to corneal homeostasis and
cell renewal. Extracellular vesicles (EVs), including exosomes (Exos), can be paracrine …