Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research

AC Montezano, RM Touyz - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) are signaling molecules that are important in
physiological processes, including host defense, aging, and cellular homeostasis. Increased …

Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies

AC Montezano, RM Touyz - Annals of medicine, 2012 - Taylor & Francis
Reactive oxygen species (ROS) are signaling molecules that influence many physiological
processes. Increased ROS bioavailability and altered redox signaling (oxidative stress) have …

[HTML][HTML] Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure—A systematic review and meta-analysis

R Bescos, L Gallardo-Alfaro, A Ashor… - Free Radical Biology …, 2024 - Elsevier
In this study, we conducted a systematic review and meta-analysis to determine plasma and
salivary nitrate (NO 3-) and nitrite (NO 2-) concentrations under resting and fasting …

[HTML][HTML] Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension

JH Amaral, GC Ferreira, LC Pinheiro, MF Montenegro… - Redox biology, 2015 - Elsevier
Hypertension is a common disease that includes oxidative stress as a major feature, and
oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular …

eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril

PS Silva, V Fontana, MR Luizon, R Lacchini… - European journal of …, 2013 - Springer
Purpose The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is
attributed partially to increased nitric oxide bioavailability. It is possible that functional …

[HTML][HTML] TEMPOL enhances the antihypertensive effects of sodium nitrite by mechanisms facilitating nitrite-derived gastric nitric oxide formation

JH Amaral, MF Montenegro, LC Pinheiro… - Free Radical Biology …, 2013 - Elsevier
Orally administered nitrite exerts antihypertensive effects associated with increased gastric
nitric oxide (NO) formation. While reducing agents facilitate NO formation from nitrite, no …

Oxidative stress markers in hypertensive states of pregnancy: preterm and term disease

LO Kurlak, A Green, P Loughna… - Frontiers in …, 2014 - frontiersin.org
Discussion continues as to whether de novo hypertension in pregnancy with significant
proteinuria (pre-eclampsia; PE) and non-proteinuric new hypertension (gestational …

[HTML][HTML] Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

TJ van't Erve - Redox biology, 2018 - Elsevier
The widespread detection of elevated oxidative stress levels in many medical conditions has
led to numerous efforts to design interventions to reduce its effects. Efforts have been wide …

Endothelial nitric oxide synthase tagSNPs influence the effects of enalapril in essential hypertension

GH Oliveira-Paula, R Lacchini, MR Luizon, V Fontana… - Nitric Oxide, 2016 - Elsevier
The antihypertensive effects of angiotensin-converting enzyme inhibitors (ACEi) are
associated with up-regulation of endothelial nitric oxide synthase (NOS3) activity. This …

Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA–salt hypertension-induced vascular dementia in rats

B Sharma, N Singh - Psychopharmacology, 2012 - Springer
Rationale Vascular dementia and hypertension are increasing day by day, with a high
degree of co-occurrence. Tremendous amount of research work is required so that new …