While Alzheimer's disease (AD) classical diagnostic criteria rely on clinical data from a
stablished symptomatic disease, newer criteria aim to identify the disease in its earlier …

Clinical diagnosis of Alzheimer's disease (AD) is based on symptoms; however, the
challenge is to diagnose AD at the preclinical stage with the application of biomarkers and …

Primary age-related tauopathy (PART) is a neurodegenerative pathology with features
distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer …

We aimed to evaluate the diagnostic role of Alzheimer's disease (AD) biomarkers in tears as
well as their association with retinal and choroidal microstructures. In a cross-sectional …

Pathologies that lead to neurodegeneration in the central nervous system (CNS) represent a
major contemporary medical challenge. Neurodegenerative processes, like those that occur …

Symptoms of normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) are
somewhat similar, and it is common to misdiagnose these two conditions. Although there are …

Background Alzheimer's disease (AD) is the 5th leading cause of death in people 65 years
and older. The ATN classification reflects a biological definition of AD pathology with …

Background In this study, we investigated the possible role of 2 novel biomarkers of synaptic
damage, namely, neurogranin and α-synuclein, in Alzheimer disease (AD). Methods The …

Background Alzheimer's disease (AD) is a continuum of events beginning with an increase
in brain soluble Aβ342 followed by the appearance of hyperphosphorylated tau (P-tau …

Background The study explores whether frailty at midlife predicts mortality and levels of
biomarkers associated with Alzheimer's disease and related dementias (ADRD) and …