Retroviruses are distinguished from other viruses by two characteristic steps in the viral
replication cycle. The first is reverse transcription, which results in the production of a double …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries
and regions of the world, and is undoubtedly the defining public-health crisis of our time …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Abstract Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA
copy of their genome after entry into the host cell. Integration of this DNA into the host cell's …

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration
complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 …

Although second-generation HIV integrase strand-transfer inhibitors (INSTIs) are prescribed
throughout the world, the mechanistic basis for the superiority of these drugs is poorly …

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular
cofactor LEDGF to effectively integrate the reverse transcript into a host cell chromosome …

Background To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA
genomes into host cell chromosomes. Lentiviral integration is favored in active transcription …