Objective Anemia is a frequent comorbidity in hemodialysis patients that can be successfully
treated by administering erythropoiesis-stimulating agents (ESAs). ESAs dosing is currently …

The objective of this paper is to give a review of the main works dealing with mathematical
modeling of blood cell formation, disorders and treatments within the past fifty years. From …

We propose a new mathematical model of erythropoiesis that takes a positive feedback of
erythrocytes on progenitor apoptosis into account, and incorporates a negative feedback of …

In this paper we present a model for erythropoiesis under the basic assumption that
sufficient iron availability is guaranteed. An extension of the model including a sub-model for …

Modeling has enabled fundamental advances in our understanding of the mechanisms of
health and disease for centuries, since at least the time of William Harvey almost 500 years …

Erythropoiesis, the process of red blood cell production, occurs mainly in the bone marrow.
The functional unit of mammalian erythropoiesis, the erythroblastic island, consists of a …

Mathematical modelling has proven an important tool in elucidating and quantifying
mechanisms that govern the age structure and population dynamics of red blood cells …

This work is devoted to mathematical modelling of erythropoiesis. We propose a new multi-
scale model, in which we bring together erythroid progenitor dynamics and intracellular …

The production and regulation of red blood cells, erythropoiesis, occurs in the bone marrow
where erythroid cells proliferate and differentiate within particular structures, called …

The erythroid lineage is a particularly sensitive target of radiation injury. We model the
dynamics of immature (BFU-E) and mature (CFU-E) erythroid progenitors, which have …