Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction
Y Mikhed, A Daiber, S Steven - International journal of molecular sciences, 2015 - mdpi.com
The prevalence of cardiovascular diseases is significantly increased in the older population.
Risk factors and predictors of future cardiovascular events such as hypertension …
Risk factors and predictors of future cardiovascular events such as hypertension …
Atg32 is a mitochondrial protein that confers selectivity during mitophagy
Mitochondrial quality control is important in maintaining proper cellular homeostasis.
Although selective mitochondrial degradation by autophagy (mitophagy) is suggested to …
Although selective mitochondrial degradation by autophagy (mitophagy) is suggested to …
Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it
K Begriche, A Igoudjil, D Pessayre, B Fromenty - Mitochondrion, 2006 - Elsevier
Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …
Somatic mitochondrial DNA mutations in mammalian aging
NG Larsson - Annual review of biochemistry, 2010 - annualreviews.org
Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …
DNA polymerase γ, the mitochondrial replicase
LS Kaguni - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract DNA polymerase (pol) γ is the sole DNA polymerase in animal mitochondria.
Biochemical and genetic evidence document a key role for pol γ in mitochondrial DNA …
Biochemical and genetic evidence document a key role for pol γ in mitochondrial DNA …
Genetic aspects of mitochondrial genome evolution
M Bernt, A Braband, B Schierwater… - Molecular phylogenetics …, 2013 - Elsevier
Many years of extensive studies of metazoan mitochondrial genomes have established
differences in gene arrangements and genetic codes as valuable phylogenetic markers …
differences in gene arrangements and genetic codes as valuable phylogenetic markers …
Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues
Mutations create genetic variation for other evolutionary forces to operate on and cause
numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly …
numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly …
Mitophagy in yeast occurs through a selective mechanism
T Kanki, DJ Klionsky - Journal of Biological Chemistry, 2008 - ASBMB
The regulation of mitochondrial degradation through autophagy is expected to be a tightly
controlled process, considering the significant role of this organelle in many processes …
controlled process, considering the significant role of this organelle in many processes …
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
Human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a
perfect paradigm of the functional complexity of a biological macromolecule. First, it plays a …
perfect paradigm of the functional complexity of a biological macromolecule. First, it plays a …