The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

NANOG is an important stem cell transcription factor involved in human development and
cancerogenesis. Its expression is complex and regulated on different levels. Moreover …

Poor prognosis in lung cancer has been attributed to the presence of lung cancer stem cells
(CSCs) which resist chemotherapy and cause disease recurrence. Hence, the strong need …

The high resistance against current therapies found in non-small-cell lung cancer (NSCLC)
has been associated to cancer stem-like cells (CSCs), a population for which the …

Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are
associated with poor prognosis. Using a Kras-induced lung cancer mouse model, CC-LR …

Lung cancer remains one of the most prominent public health challenges, accounting for the
highest incidence and mortality among all human cancers. While pulmonary invasive …

Despite recent advances in the treatment of non-small cell lung cancer (NSCLC), less than
10% of patients survive the first five years when the disease has already spread at primary …

Background: Lung cancer stem cells (CSCs) share many characteristics with normal stem
cells, such as self-renewal and multipotentiality. High expression of aldehyde …

Cancer stem cells (CSCs) play major roles in tumor initiation, progression, and resistance to
cancer therapy. Several CSC markers have been studied in head and neck squamous cell …

Multiple theories exist to explain cancer initiation, although a consensus on this is crucial for
developing effective therapies.'Somatic mutation theory'suggests that mutations in somatic …