Lung cancer is the leading cause of cancer death in the United States. Despite evidence of
molecular abnormalities in biological specimens, progress in this disease is hampered by …

Mechanisms mediating tumor cell attachment to the vessel wall under flow conditions are
largely unknown. Therefore we analyzed the ability of human melanoma cells to adhere to …

Inhalation of iloprost, a stable prostacyclin (PGI2) analog, is a well-accepted and safe
treatment for pulmonary arterial hypertension. Although iloprost mainly acts as a vasodilator …

More than a decade ago, prostacyclin, a dienoic bicyclic eicosanoid derived from the
metabolism of arachidnoic acid, was found to possess potent inhibitory effects on tumor cell …

Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of
the central nervous system (CNS). It is an animal model of post-infectious encephalomyelitis …

Recent studies have shown that a bioactive lipid prostacyclin (PGI 2) plays a role in various
cancers, including lung cancer. However, the specific function of PGI 2 in ovarian cancer …

Abstract Prostaglandin I2 (PGI2) agonist has been reported to reduce tumor metastasis by
modifying tumor angiogenesis; however, the mechanisms of how PGI2 affects the …

Nitric oxide and other reactive oxygen species generated by nitric-oxide synthases (NOS)
modulate, among several other cellular responses, the production of eicosanoids and …

Nonterminal blood sampling in laboratory mice is a very common procedure. With the goal
of improving animal welfare, different sampling sites and methods have been compared but …

The inbred nonobese diabetic (NOD) mouse spontaneously develops an autoimmune
diabetes, which is now recognized as an experimental model for human type I insulin …