Kinetic mechanism of DNA polymerases: contributions of conformational dynamics and a third divalent metal ion
Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …
polymerases. During DNA replication, these enzymes catalyze incorporation of …
Brief research on the biophysical study and anticancer behavior of Pt (II) complexes: their DNA/BSA binding, molecular docking, and cytotoxic property
The potent bidentate carrier ligand 2-picolylamine (pic) has been used to synthesize Pt (II)
complexes to know their bioactivity and anticancer property as reflected by PASS prediction …
complexes to know their bioactivity and anticancer property as reflected by PASS prediction …
Influence of DNA lesions on polymerase-mediated DNA replication at single-molecule resolution
Faithful replication of DNA is a critical aspect in maintaining genome integrity. DNA
polymerases are responsible for replicating DNA, and high-fidelity polymerases do this …
polymerases are responsible for replicating DNA, and high-fidelity polymerases do this …
[HTML][HTML] Conformational transitions of Streptococcus pyogenes Cas9 induced by salt and single-guide RNA binding
Y He, N Zalenski, AA Stephenson, AT Raper… - Journal of Biological …, 2024 - Elsevier
ABSTRACT Streptococcus pyogenes (Sp) Cas9 has been widely utilized to edit genomes
across diverse species. To achieve high efficiency and specificity as a gene editing enzyme …
across diverse species. To achieve high efficiency and specificity as a gene editing enzyme …
Mechanistic Studies of DNA Replication, Lesion Bypass, and Editing
AT Raper - 2018 - rave.ohiolink.edu
DNA acts as a molecular blueprint for life. Adenosine, cytidine, guanosine, and thymidine
nucleotides serve as the building blocks of DNA and can be arranged in near-endless …
nucleotides serve as the building blocks of DNA and can be arranged in near-endless …
A Structural and Biochemical Investigation of Human DNA Polymerase Beta
AJ Reed - 2018 - rave.ohiolink.edu
Adenosine, guanosine, cytidine, and thymidine nucleotides are the building blocks of life
and are arranged in distinct combinations to give unique genomic DNA sequences. These …
and are arranged in distinct combinations to give unique genomic DNA sequences. These …
Real-Time Investigation Of Bulky Lesion Bypass By Y-Family Dna Polymerase, Dpo4, Using Single Molecule Fret
P Liyanage - 2017 - digitalcommons.wayne.edu
DNA is constantly exposed to various DNA damaging agents that are generated by various
internal and external sources. Some of this damage may not be able to be repaired by …
internal and external sources. Some of this damage may not be able to be repaired by …