Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …
indispensable for cellular survival due to the numerous roles they play during DNA …
Cellular roles of DNA topoisomerases: a molecular perspective
JC Wang - Nature reviews Molecular cell biology, 2002 - nature.com
DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …
double helices to pass through each other, they can solve all of the topological problems of …
New mechanistic and functional insights into DNA topoisomerases
SH Chen, NL Chan, T Hsieh - Annual review of biochemistry, 2013 - annualreviews.org
DNA topoisomerases are nature's tools for resolving the unique problems of DNA
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation
Tudor domain-containing protein 3 (TDRD3) is a major methylarginine effector molecule that
reads methyl-histone marks and facilitates gene transcription. However, the underlying …
reads methyl-histone marks and facilitates gene transcription. However, the underlying …
Knockouts model the 100 best-selling drugs—will they model the next 100?
BP Zambrowicz, AT Sands - Nature reviews Drug discovery, 2003 - nature.com
The biopharmaceutical industry is currently faced with a tremendous number of potential
drug targets identified through the sequencing of the human genome. The challenge ahead …
drug targets identified through the sequencing of the human genome. The challenge ahead …
Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan
Fibronectins (FNs) are multifunctional high molecular weight glycoproteins present in the
blood plasma and in the ECMs of tissues. The FN primary transcript undergoes alternative …
blood plasma and in the ECMs of tissues. The FN primary transcript undergoes alternative …
Type i DNA topoisomerases
G Capranico, J Marinello… - Journal of medicinal …, 2017 - ACS Publications
DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …
of life. Although they share general reaction chemistry and the capacity to govern DNA …
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Topoisomerases are crucial for solving DNA topological problems, but they have not been
linked to RNA metabolism. Here we show that human topoisomerase 3β (Top3β) is an RNA …
linked to RNA metabolism. Here we show that human topoisomerase 3β (Top3β) is an RNA …
DNA topology and topoisomerases: teaching a “knotty” subject
JE Deweese, MA Osheroff… - … and Molecular Biology …, 2009 - Wiley Online Library
DNA is essentially an extremely long double‐stranded rope in which the two strands are
wound about one another. As a result, topological properties of the genetic material …
wound about one another. As a result, topological properties of the genetic material …