Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …

Very long-chain fatty acids (VLCFAs) are fatty acids (FAs) with a chain-length of≥ 22
carbons. Mammals have a variety of VLCFAs differing in chain-length and the number of …

Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1
(mTORC1), which functions both as a nutrient sensor and a master controller of virtually all …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

The yeast Saccharomyces cerevisiae is a powerful experimental system to study
biochemical, cell biological and molecular biological aspects of lipid synthesis. Most but not …

Ceramide (Cer) is a structural backbone of sphingolipids and is composed of a long-chain
base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length …

Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae
does not feed typically on fatty acids, cellular function and growth relies on endogenous …

Acetyl-CoA carboxylase (ACCase) catalyzes the first committed step of fatty acid synthesis,
the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes …

Very‐long‐chain fatty acids (VLCFAs) are essential precursors of cuticular waxes and
aliphatic suberins in roots. The first committed step in VLCFA biosynthesis is condensation …

Stargardt-like macular dystrophy (STGD3) is a dominantly inherited juvenile macular
degeneration that eventually leads to loss of vision. Three independent mutations causing …