Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …

The instability of messenger RNA is fundamental to the control of gene expression. In
bacteria, mRNA degradation generally follows an “all-or-none” pattern. This implies that if …

Tools for synthetically controlling gene expression are a cornerstone of genetic engineering.
CRISPRi and CRISPRa technologies have been applied extensively for programmable …

Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and
thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease …

RNA processing and degradation are key processes in the control of transcript accumulation
and thus in the control of gene expression. In Escherichia coli, the underlying mechanisms …

RNase Y of Bacillus subtilis is a key member of the degradosome and important for bulk
mRNA turnover. In contrast to B. subtilis, the RNase Y homologue (rny/cvfA) of …

RNA degradation is an essential process that allows bacteria to control gene expression
and adapt to various environmental conditions. It is usually initiated by endoribonucleases …

ABSTRACT RNA endonucleases are the rate-limiting initiator of decay for many bacterial
mRNAs. However, the positions of cleavage and their sequence determinants remain …

The regulation of RNA decay is now widely recognized as having a central role in bacterial
adaption to environmental stress. Here we present an overview on the diversity of …

RNase Y is a key endoribonuclease affecting global mRNA stability in Bacillus subtilis. Its
characterization provided the first evidence that endonucleolytic cleavage plays a major role …