The idea of “reasonableness” of organic reactions is based on recorded evidence of
reaction patterns. The logical patterns are organized based on structural and functional …

Abstract ULLMANN'S Encyclopedia of Industrial Chemistry is the benchmark reference in
chemistry and chemical and life science engineering, covering inorganic and organic …

The use of masked functional groups such as masked acyl anion equivalents in the
formation of CC bonds has proved to be a powerful strategy in the development of new …

Thiamin diphosphate (ThDP), the vitamin B1 coenzyme, is an excellent representative of
coenzymes, which carry out electrophilic catalysis by forming a covalent complex with their …

Enzymic catalysis proceeds via intermediates formed in the course of substrate conversion.
Here, we directly detect key intermediates in thiamin diphosphate (ThDP)-dependent …

The conjugate addition of carbonyl anions catalyzed by thiazolium salts that is fully operative
under neutral aqueous conditions has been accomplished. The combination of α-keto …

The bacterial metabolic enzyme 1-deoxy-d-xylulose-5-phosphate synthase (DXPS)
catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and d …

Enzymes that use the cofactor thiamin diphosphate (ThDP, 1), the biologically active form of
vitamin B1, are involved in numerous metabolic pathways in all organisms. Although a …

The thiamin diphosphate (ThDP)-dependent enzyme 1-deoxy-d-xylulose 5-phosphate
(DXP) synthase carries out the condensation of pyruvate as a 2-hydroxyethyl donor with d …

The reductive tricarboxylic acid (rTCA) cycle is among the most plausible candidates for the
first autotrophic metabolism in the earliest life. Extant enzymes fixing CO2 in this cycle …