Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications

MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

Bioactive compounds and their derivatives: an insight into prospective phytotherapeutic approach against alzheimer's disease

F Islam, JF Khadija, M Harun-Or-Rashid… - Oxidative Medicine …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a common neurodegenerative brain disorder that causes
cellular response alterations, such as impaired cholinergic mechanism, amyloid‐beta (Aβ) …

Molecular insight into the therapeutic promise of flavonoids against Alzheimer's disease

MS Uddin, MT Kabir, K Niaz, P Jeandet, C Clément… - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is one of the utmost chronic neurodegenerative disorders, which is
characterized from a neuropathological point of view by the aggregates of amyloid beta (Aβ) …

Autophagic dysfunction in Alzheimer's disease: cellular and molecular mechanistic approaches to halt Alzheimer's pathogenesis

MS Uddin, AA Mamun, ZK Labu… - Journal of cellular …, 2019 - Wiley Online Library
Autophagy is a preserved cytoplasmic self‐degradation process and endorses recycling of
intracellular constituents into bioenergetics for the controlling of cellular homeostasis …

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

MF Nisar, J He, A Ahmed, Y Yang, M Li, C Wan - Molecules, 2018 - mdpi.com
Medicinal plants have served humans since prehistoric times to treat various ailments. Both
developed and underdeveloped countries rely on traditional systems of medication using …

Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift …

MS Uddin, AA Mamun, MS Hossain, F Akter… - Annals of …, 2016 - karger.com
Neurodegenerative diseases are incurable and debilitating conditions that result in the
progressive degeneration of nerve cells, which affect the cognitive activity. Currently, as a …

NMDA receptor antagonists: repositioning of memantine as a multitargeting agent for Alzheimer's therapy

MT Kabir, MA Sufian, MS Uddin… - Current …, 2019 - benthamdirect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes problems
with memory, thinking, and behavior. Currently, there is no drug that can reduce the …

Amelioration of cognitive deficit by embelin in a scopolamine-induced Alzheimer's disease-like condition in a rat model

S Bhuvanendran, Y Kumari, I Othman… - Frontiers in …, 2018 - frontiersin.org
Embelin (2, 5-dihydroxy-3-undecyl-1, 4-benzoquinone) is one of the active components
(2.3%) found in Embelia ribes Burm fruits. As determined via in vitro AChE inhibition assay …

Oxidative stress in Alzheimer's disease: molecular hallmarks of underlying vulnerability

MS Uddin, MT Kabir - Biological, Diagnostic and Therapeutic Advances in …, 2019 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs) in the hippocampus …