Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …

There is increasing interest in the use of inhaled aerosol drug therapy for the treatment of
tuberculosis (TB). A number of methods of preparation of particles have been employed …

Treatment for tuberculosis (TB) using the standard oral antibiotic regimen is effective but
inefficient, requiring high drug dosing and lengthy treatment times. Three concurrent first-line …

We investigated whether particles suitable for delivery to alveolar macrophages may provide
a means of targeting rapamycin, an inducer of autophagy, to alveolar macrophages as a …

A polyelectrolyte complex based on chitosan and carrageenan was used to coat rifampicin-
loaded vesicles and obtain a dry powder for inhalation by spray-drying. The polymer …

The effects of lipid concentration and composition on the physicochemical properties,
aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were …

Objectives In this work, a new polymeric microparticle system based on gelatin covalently
bound to isoniazid (ISN) and containing rifampicin (RFP) was prepared by spray-drying …

We investigated the preclinical efficacy and safety/tolerability of biodegradable polymeric
particles containing isoniazid (INH) and rifabutin (RFB) dry powder for inhalation (DPI) as an …

Successes in the field of respiratory medicines are largely limited to three main target
classes: β2‐adrenergic receptor agonists, muscarinic antagonists and corticosteroids. A …

In the present investigation inhaled isoniazid microparticles (IM) and isoniazid polymeric
microparticles (INH-PM) using poly-ɛ-caprolactone polymer were prepared through spray …